background: in this study, the protective effect of thymoquinone (tq) and nigella sativa seeds oil (nso) was evaluated against oxidative damages induced by ethanol in rats. methods: animals were treated with ethanol 40% daily by gavages once a day for 4 weeks. nso and tq were injected intraperitoneal once a day for 4 weeks. the histopathological examination of liver, kidney, brain and heart was...

objective(s):this study was planned to appraise the protective effect of nigella sativa fixed oil (nso) against subchronic ethanol induced toxicity in rats. materials and methods: studies were carried out on six groups of six animals each, including control (normal saline, gavage), ethanol (3 g/kg/day, gavage), nso (0.125, 0.25 and 0.5 ml/kg/day, ip) plus ethanol and nso (0.5 ml/kg/day, ip) gro...

Objective(s): Long term consumption of ethanol may induce damage to many organs. Ethanol induces its noxious effects through reactive oxygen species production, and lipid peroxidation and apoptosis induction in different tissues and cell types. Previous experiments have indicated the antioxidant characteristics of thymoquinone, the active constituent of Nigella sativa fixed oil, against biologi...

The role of alcohols in potentiating the toxicity of halogenated hydrocarbon solvents has been reviewed. The toxicity of carbon tetrachloride and chloroform can be markedly potentiated by prior treatment with ethanol or phenobarbital. Trichloroethylene toxicity may also be potentiated by ethanol ingestion. Prior ethanol ingestion acts by altering biochemical parameters that result in an increas...

The molecular mechanisms of ethanol toxicity and tolerance in bacteria, although important for biotechnology and bioenergy applications, remain incompletely understood. Genetic studies have identified potential cellular targets for ethanol and have revealed multiple mechanisms of tolerance, but it remains difficult to separate the direct and indirect effects of ethanol. We used adaptive evoluti...

Olives and olive oil contain large amounts of oleuropein. This phenolic compound is responsible for theirbitter taste and pungent aroma and has been recognized as a powerful hypotensive, hypoglycemic andantioxidant agent. Thus, the aim of the present study was to evaluate the antioxidant properties of oleuropein on ethanol-induced oxidative damage and to examine its beneficial effects on liver ...

olives and olive oil contain large amounts of oleuropein. this phenolic compound is responsible for theirbitter taste and pungent aroma and has been recognized as a powerful hypotensive, hypoglycemic andantioxidant agent. thus, the aim of the present study was to evaluate the antioxidant properties of oleuropein on ethanol-induced oxidative damage and to examine its beneficial effects on liver ...